The ER exit sites are specialized ER zones for the transport of cargo proteins from the ER to the Golgi apparatus | Zendy

Kazuo Kurokawa | Zendy; Akihiko Nakano | Zendy

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The ER exit sites are specialized ER zones for the transport of cargo proteins from the ER to the Golgi apparatus

Author(s) -

Kazuo Kurokawa,

Akihiko Nakano

Publication year - 2018

Publication title -

the journal of biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 115

eISSN - 1756-2651

pISSN - 0021-924X

DOI - 10.1093/jb/mvy080

Subject(s) - copii , endoplasmic reticulum , golgi apparatus , copi , biogenesis , microbiology and biotechnology , organelle , secretory pathway , transport protein , membrane contact site , vesicular transport proteins , vesicle , chemistry , secretory protein , unfolded protein response , biology , secretion , membrane protein , biochemistry , membrane , endosome , integral membrane protein , gene , vacuolar protein sorting , intracellular

The endoplasmic reticulum (ER) is a multifunctional organelle, including secretory protein biogenesis, lipid synthesis, drug metabolism, Ca2+ signalling and so on. Since the ER is a single continuous membrane structure, it includes distinct zones responsible for its different functions. The export of newly synthesized proteins from the ER is facilitated via coat protein complex II (COPII)-coated vesicles, which form in specialized zones within the ER, called the ER exit sites (ERES) or transitional ER. In this review, we highlight recent advances in our understanding of the structural organization of ERES, the correlation between the ERES and Golgi organization, and the faithful cargo transport mechanism from the ERES to the Golgi.

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