Postsynaptic density proteins and their involvement in neurodevelopmental disorders | Zendy

Takeshi Kaizuka | Zendy; Toru Takumi | Zendy

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Postsynaptic density proteins and their involvement in neurodevelopmental disorders

Author(s) -

Takeshi Kaizuka,

Toru Takumi

Publication year - 2018

Publication title -

the journal of biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 115

eISSN - 1756-2651

pISSN - 0021-924X

DOI - 10.1093/jb/mvy022

Subject(s) - postsynaptic density , scaffold protein , postsynaptic potential , neuroscience , synaptic plasticity , excitatory postsynaptic potential , neurotransmission , biology , inhibitory postsynaptic potential , microbiology and biotechnology , receptor , signal transduction , biochemistry

Synaptic connections are essential for neural circuits in order to convey brain functions. The postsynaptic density (PSD) is a huge protein complex associated with postsynaptic membranes of excitatory synapses. In mammals, the PSD is composed of more than 1,000 proteins including receptors, scaffold proteins, signalling enzymes and cytoskeletal proteins. PSD proteins are crucial for synaptic transmission and plasticity. Proteomic studies have revealed the composition of PSD proteins in various species, brain regions and specific physiological conditions. Abnormalities with PSD proteins are linked to various neuropsychiatric diseases including neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. Here, we review different kinds of proteomic studies of the PSD and the involvement of PSD proteins in physiological and pathological conditions.

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