Open AccessNotch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators
Author(s) -
Motoo Kitagawa
Publication year - 2015
Publication title -
the journal of biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 115
eISSN - 1756-2651
pISSN - 0021-924X
DOI - 10.1093/jb/mvv123
Subject(s) - notch signaling pathway , nucleus , microbiology and biotechnology , biology , signalling , transcription factor , gene , signal transduction , genetics
Notch signalling plays pivotal roles in development and homeostasis of all metazoan species. Notch is a receptor molecule that directly translates information of cell-cell contact to gene expression in the nucleus. Mastermind is a conserved and essential nuclear factor that supports the activity of Notch. Here, the past and current studies of the interplay between these factors are reviewed.
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