A new link between the retrograde actin flow and focal adhesions | Zendy

Sawako Yamashiro | Zendy; Naoki Watanabe | Zendy

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A new link between the retrograde actin flow and focal adhesions

Author(s) -

Sawako Yamashiro,

Naoki Watanabe

Publication year - 2014

Publication title -

the journal of biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 115

eISSN - 1756-2651

pISSN - 0021-924X

DOI - 10.1093/jb/mvu053

Subject(s) - focal adhesion , actin , microbiology and biotechnology , cell adhesion molecule , actin remodeling , cell adhesion , actin cytoskeleton , tractive force , chemistry , cell , biology , biophysics , cytoskeleton , biochemistry , physics , signal transduction , thermodynamics

The retrograde actin flow, continuous centripetal movement of the cell peripheral actin networks, is widely observed in adherent cells. The retrograde flow is believed to facilitate cell migration when linked to cell adhesion molecules. In this review, we summarize our current knowledge regarding the functional relationship between the retrograde actin flow and focal adhesions (FAs). We also introduce our recent study in which single-molecule speckle (SiMS) microscopy dissected the complex interactions between FAs and the local actin flow. FAs do not simply impede the actin flow, but actively attract and remodel the local actin network. Our findings provide a new insight into the mechanisms for protrusion and traction force generation at the cell leading edge. Furthermore, we discuss possible roles of the actin flow-FA interaction based on the accumulated knowledge and our SiMS study.

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