Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions | Zendy

Shunsuke Takasuga | Zendy; Takehiko Sasaki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions

Author(s) -

Shunsuke Takasuga,

Takehiko Sasaki

Publication year - 2013

Publication title -

the journal of biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 115

eISSN - 1756-2651

pISSN - 0021-924X

DOI - 10.1093/jb/mvt064

Subject(s) - phosphatidylinositol , dephosphorylation , inositol , diacylglycerol kinase , phosphorylation , kinase , phosphatase , biochemistry , phosphatidylinositol 4,5 bisphosphate , microbiology and biotechnology , biology , enzyme , phospholipid , chemistry , membrane , protein kinase c , receptor

Phosphatidylinositol (PtdIns) is a membrane phospholipid composed of diacylglycerol and a D-myo-inositol head group. In mammals, the hydroxyl groups at the D3, D4 and D5 positions of the inositol ring can be phosphorylated to yield seven phosphoinositide derivatives. PtdIns-3,5-bisphosphate [PtdIns(3,5)P2] is the most recently discovered species of phosphoinositide that is generated by the phosphorylation of PtdIns(3)P at the D5 position by PtdIns phosphate kinase and catabolized through the dephosphorylation by myotubularin family of phosphatases. Genetic and biochemical analyses of the enzymes metabolizing PtdIns(3,5)P2 have revealed that this phospholipid is involved in the control of endolysosomal systems and plays crucial roles in various mammalian tissues. In this article, we review the current state of knowledge of the metabolic/physiological functions of PtdIns(3,5)P2, and describe how disruption of these functions may contribute to human diseases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research