Transient Expression of Bone Morphogenic Protein-2 in Acute Liver Injury by Carbon Tetrachloride | Zendy

Rie Nakatsuka | Zendy; Makoto Taniguchi | Zendy; Maki Hirata | Zendy; Goshi Shiota | Zendy; Kei Sato | Zendy

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Transient Expression of Bone Morphogenic Protein-2 in Acute Liver Injury by Carbon Tetrachloride

Author(s) -

Rie Nakatsuka,

Makoto Taniguchi,

Maki Hirata,

Goshi Shiota,

Kei Sato

Publication year - 2006

Publication title -

the journal of biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 115

eISSN - 1756-2651

pISSN - 0021-924X

DOI - 10.1093/jb/mvm012

Subject(s) - carbon tetrachloride , immunostaining , ccl4 , liver injury , bone morphogenetic protein , albumin , bone morphogenetic protein 2 , pathology , gene expression , chemistry , biology , microbiology and biotechnology , medicine , gene , immunohistochemistry , endocrinology , biochemistry , in vitro , organic chemistry

Acute liver injury induced by administration of carbon tetrachloride (CCl4) was shown to be a model of wound-repair in rat liver. Albumin gene expression was significantly reduced at 24 h post injection with CCl4, but recovered at 48 h. We also observed significant and transient expression of bone morphogenic protein-2 (BMP-2) at 6-24 h post treatment. This expression was also shown with depletion of Kupffer cell by GdCl3, and immunostaining with anti-BMP-2 antibody showed BMP-2-producing cells interspersed in intralobular spaces of injured liver. These observations suggest that BMP-2 secreted from oval-like cells plays important roles in the wound healing response of injured liver.

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