Discordant Umbilical Cord Drug Testing Results in Monozygotic Twins | Zendy

Amy L. Alexander | Zendy; Liaqat Abbas | Zendy; Mary Jones | Zendy; Joseph Jones | Zendy; Douglas Lewis | Zendy; Adam Negrusz | Zendy

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Discordant Umbilical Cord Drug Testing Results in Monozygotic Twins

Author(s) -

Amy L. Alexander,

Liaqat Abbas,

Mary Jones,

Joseph Jones,

Douglas Lewis,

Adam Negrusz

Publication year - 2018

Publication title -

journal of analytical toxicology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.161

H-Index - 76

eISSN - 1945-2403

pISSN - 0146-4760

DOI - 10.1093/jat/bky009

Subject(s) - hydromorphone , umbilical cord , benzoylecgonine , medicine , anesthesia , metabolite , immunology , opioid , receptor

Our laboratory received segments of umbilical cord that originated from identical twins for routine toxicology analysis. The specimens were analyzed multiple times by liquid chromatography tandem mass spectrometry. The umbilical cord from newborn #1 was positive for hydromorphone only (1.06 ng/g), and the umbilical cord from newborn #2 was positive for hydromorphone (0.81 ng/g) and benzoylecgonine (5.41 ng/g). The hydromorphone results are consistent with maternal administration of hydromorphone; however, the cause of the discrepant benzoylecgonine results in the umbilical cords from the identical twins is unknown.

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