Pregabalin Determination in Hair by Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry | Zendy

Caroline Pauly | Zendy; Michel Yegles | Zendy; Serge Schneider | Zendy

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Pregabalin Determination in Hair by Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry

Author(s) -

Caroline Pauly,

Michel Yegles,

Serge Schneider

Publication year - 2013

Publication title -

journal of analytical toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.161

H-Index - 76

eISSN - 1945-2403

pISSN - 0146-4760

DOI - 10.1093/jat/bkt081

Subject(s) - pregabalin , chromatography , detection limit , chemistry , tandem mass spectrometry , mass spectrometry , extraction (chemistry) , analgesic , liquid chromatography–mass spectrometry , pharmacology , medicine , anesthesia

Pregabalin is an antiepileptic and analgesic drug, commercialized under the name of Lyrica, and generally used to treat neuropathic pain. The determination of pregabalin was performed by using spiked hair samples extracted in methanol and analyzed by ultra-high-performance liquid chromatography coupled with tandem mass spectrometry. The validation of a quantification method of pregabalin in hair has been successfully achieved (precision, accuracy, matrix effects and extraction yield). The limit of detection was 0.76 pg/mg and the lower limit of quantification was 2.5 pg/mg. A real case of pregabalin in hair has been analyzed using this method. The result showed a concentration of 540 pg/mg.

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