An HPLC-HR-MS-MS Method for Identification of Anticoagulant Rodenticides in Blood | Zendy

Jason E. Schaff | Zendy; M. A. Montgomery | Zendy

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An HPLC-HR-MS-MS Method for Identification of Anticoagulant Rodenticides in Blood

Author(s) -

Jason E. Schaff,

M. A. Montgomery

Publication year - 2013

Publication title -

journal of analytical toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.161

H-Index - 76

eISSN - 1945-2403

pISSN - 0146-4760

DOI - 10.1093/jat/bkt036

Subject(s) - brodifacoum , chromatography , analyte , chemistry , solid phase extraction , high performance liquid chromatography , tandem mass spectrometry , mass spectrometry , rodenticide , organic chemistry

This paper presents a fully validated method for the qualitative identification of bromadiolone, brodifacoum, coumachlor, coumatetralyl, difenacoum and warfarin in whole blood specimens. Samples are protein precipitated with acetonitrile, processed via solid-phase extraction and analyzed by high-performance liquid chromatography with high resolution tandem mass spectrometric detection. Limits of detection were 10 ng/mL or better for all analytes.

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