Unstable Propoxyphene Metabolite Excreted in Human Urine is Detected by Liquid Chromatography-Tandem Mass Spectrometry | Zendy

Bridgit Crews | Zendy; Charles Mikel | Zendy; Sergey Latyshev | Zendy; Robert West | Zendy; Amadeo J. Pesce | Zendy

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Unstable Propoxyphene Metabolite Excreted in Human Urine is Detected by Liquid Chromatography-Tandem Mass Spectrometry

Author(s) -

Bridgit Crews,

Charles Mikel,

Sergey Latyshev,

Robert West,

Amadeo J. Pesce

Publication year - 2009

Publication title -

journal of analytical toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.161

H-Index - 76

eISSN - 1945-2403

pISSN - 0146-4760

DOI - 10.1093/jat/33.7.379

Subject(s) - chemistry , chromatography , metabolite , mass spectrometry , urine , tandem mass spectrometry , liquid chromatography–mass spectrometry , propoxyphene , extraction (chemistry) , biochemistry , medicine , analgesic , pharmacology

A "dilute and shoot" method for measuring norpropoxyphene in human urine using liquid chromatography-tandem mass spectrometry distinguishes two different metabolites of propoxyphene, norpropoxyphene (m/z 326) and a dehydrated rearrangement product (m/z 308). The metabolite formed from the rearrangement and dehydration of norpropoxyphene is excreted in human urine and also may be formed from the chemical degradation of norpropoxyphene. Previously, these two metabolites were indistinguishable by gas chromatography- mass spectrometry methods that use an alkaline extraction that converts norpropoxyphene into its rearrangement product. The degradation of norpropoxyphene presents a challenge for its analytical quantitation, and methods for circumventing these issues are presented.

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