Tizanidine Distribution in a Postmortem Case
Author(s) -
J. H. Sklerov,
D. E. Cox,
Kathleen A. Moore,
Barry Levine,
David R. Fowler
Publication year - 2006
Publication title -
journal of analytical toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.161
H-Index - 76
eISSN - 1945-2403
pISSN - 0146-4760
DOI - 10.1093/jat/30.5.331
Subject(s) - tizanidine , diazepam , autopsy , medicine , medical examiner , distribution (mathematics) , forensic toxicology , ethanol , anesthesia , emergency medicine , poison control , chemistry , injury prevention , chromatography , mathematical analysis , mathematics , spasticity , organic chemistry
The case of a 57-year-old white female who was found deceased at home by her husband is presented. A suicide note was found at the scene. No remarkable findings were observed at autopsy. Comprehensive toxicological analysis of the heart blood identified ethanol (0.16 g/dL), diazepam (1.1 mg/L), and tizanidine (2.3 mg/L). Blood concentrations of tizanidine following therapeutic use do not exceed 0.025 mg/L. The medical examiner ruled that the cause of death was combined ethanol and multiple drug intoxication, and the manner of death was suicide.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom