Analysis of Strychnine and Brucine in Postmortem Specimens by RP-HPLC: A Case Report of Fatal Intoxication | Zendy

Zhi Wang | Zendy; Jian Zhao | Zendy; Jie Xing | Zendy; Ye He | Zendy; Dean Guo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Analysis of Strychnine and Brucine in Postmortem Specimens by RP-HPLC: A Case Report of Fatal Intoxication

Author(s) -

Zhi Wang,

Jian Zhao,

Jie Xing,

Ye He,

Dean Guo

Publication year - 2004

Publication title -

journal of analytical toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.161

H-Index - 76

eISSN - 1945-2403

pISSN - 0146-4760

DOI - 10.1093/jat/28.2.141

Subject(s) - brucine , strychnine , strychnos , chromatography , high performance liquid chromatography , detection limit , chemistry , quantitative analysis (chemistry) , solid phase extraction , alkaloid , stereochemistry , biochemistry

A sensitive method for the identification and quantitation of the toxic alkaloids strychnine and brucine from postmortem specimens has been established. After solid-phase extraction using Oasis MCX cartridges the extracts were analyzed by high-performance liquid chromatography with diode-array detection. The limit of detection was 0.5 ng/mL blood for strychnine and brucine, and the limit of quantitation was 5 ng/mL blood for strychnine and brucine. The method was applied for the analysis of blood and gastric contents of a 34-year-old female who died after ingestion of a packet of herbal medicine powder containing the seeds of Strychnos nux-vomica L. Strychnine and brucine were detected in all the samples. The concentration in our case is consistent with that in previous reports.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research