Fatal Overdosage with Cisplatin | Zendy

Corinne Charlier | Zendy; Pascal Kintz | Zendy; Nathalie Dubois | Zendy; G Plomteux | Zendy

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Fatal Overdosage with Cisplatin

Author(s) -

Corinne Charlier,

Pascal Kintz,

Nathalie Dubois,

G Plomteux

Publication year - 2004

Publication title -

journal of analytical toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.161

H-Index - 76

eISSN - 1945-2403

pISSN - 0146-4760

DOI - 10.1093/jat/28.2.138

Subject(s) - cisplatin , ototoxicity , medicine , urine , dialysis , nephrotoxicity , antidote , pancytopenia , urology , pharmacology , kidney , anesthesia , chemistry , chemotherapy , toxicity , bone marrow

This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart and peripheral blood concentrations of platinum were 1515 and 1253 micro g/L, respectively. Concentrations in urine and bile were 1038 and 501 micro g/L, respectively. Renal dialysis was started immediately after the end of cisplatin perfusion, when the mistake was noticed, but the patient deceased at day 16, presenting renal and hepatic insufficiency, ototoxicity, and pancytopenia.

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