Acute Nitrobenzene Poisoning with Severe Associated Methemoglobinemia: Identification in Whole Blood by GC—FID and GC-MS | Zendy

M. A. Martinez | Zendy; S. Ballesteros | Zendy; E. Almarza | Zendy; Carolina Sánchez de la Torre | Zendy; S. Búa | Zendy

Open Access

Acute Nitrobenzene Poisoning with Severe Associated Methemoglobinemia: Identification in Whole Blood by GC—FID and GC-MS

Author(s) -

M. A. Martinez,

S. Ballesteros,

E. Almarza,

Carolina Sánchez de la Torre,

S. Búa

Publication year - 2003

Publication title -

journal of analytical toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.161

H-Index - 76

eISSN - 1945-2403

pISSN - 0146-4760

DOI - 10.1093/jat/27.4.221

Subject(s) - methemoglobinemia , nitrobenzene , ingestion , gas chromatography–mass spectrometry , methemoglobin , chromatography , chemistry , medicine , anesthesia , hemoglobin , mass spectrometry , organic chemistry , catalysis

A rare fatal case of self-poisoning with nitrobenzene following oral ingestion is reported. On presentation to the hospital, severe methemoglobinemia (70%) was observed in an 82-year-old male who had ingested 250 mL of an unknown substance in the previous 24 h. Methylene blue and exchange transfusion were the therapeutic methods applied in the treatment of the methemoglobinemia. Forty-eight hours after ingestion, a blood sample was collected in ICU and sent to our laboratory. We detected that the blood contained 3.2 microg/mL of nitrobenzene. The determination of nitrobenzene was performed using the combination of GC-FID for screening analysis and quantitation and GC-MS for confirmation of the obtained results.

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