Quantitation of Morphine and Codeine in Human Urine using High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) with Mass Spectrometric Detection | Zendy

Margaret McCooeye | Zendy; Barbara Ells | Zendy; David A. Barnett | Zendy; Randy W. Purves | Zendy; Roger Guevremont | Zendy

Open Access

Quantitation of Morphine and Codeine in Human Urine using High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) with Mass Spectrometric Detection

Author(s) -

Margaret McCooeye,

Barbara Ells,

David A. Barnett,

Randy W. Purves,

Roger Guevremont

Publication year - 2001

Publication title -

journal of analytical toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.161

H-Index - 76

eISSN - 1945-2403

pISSN - 0146-4760

DOI - 10.1093/jat/25.2.81

Subject(s) - chemistry , chromatography , codeine , ion mobility spectrometry , mass spectrometry , detection limit , derivatization , electrospray , electrospray ionization , morphine , tandem mass spectrometry , urine , pharmacology , medicine , biochemistry

Morphine and codeine have been identified and measured in a human urine matrix using high-field asymmetric waveform ion mobility spectrometry (FAIMS) in a tandem combination with electrospray ionization (ESI) and mass spectrometric (MS) detection. The addition of helium to the nitrogen carrier gas resulted in a substantial improvement in the sensitivity of the ESI-FAIMS-MS instrument for the determination of morphine and codeine. Limits of detection in human urine were 60 ng/mL for morphine and 20 ng/mL for codeine with no clean-up, derivatization, or chromatographic separation of the sample prior to analysis.

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