Procainamide Inhibition of Human Hepatic Degradation of Cocaine and Cocaethylene In Vitro | Zendy

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Procainamide Inhibition of Human Hepatic Degradation of Cocaine and Cocaethylene In Vitro

Author(s) -

David N. Bailey

Publication year - 1999

Publication title -

journal of analytical toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.161

H-Index - 76

eISSN - 1945-2403

pISSN - 0146-4760

DOI - 10.1093/jat/23.3.173

Subject(s) - procainamide , cardiotoxicity , pharmacology , chemistry , in vitro , ethanol , drugs of abuse , drug , toxicity , biochemistry , medicine , organic chemistry

Procainamide (PA), a cardioactive drug, inhibited the degradation of both cocaine (COC) and cocaethylene (CE) when either was incubated in human liver homogenates for 3 h at 37 degrees C. PA appeared to enhance the formation of CE when COC and ethanol (ETOH) were incubated together in liver homogenate. These observations are clinically significant because cardiotoxicity is common after COC abuse and because PA may be administered to individuals who use COC alone and with ETOH.

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