Concentrations of Heroin, 06-Monoacetylmorphine, and Morphine in a Lethal Case Following an Oral Heroin Overdose | Zendy

Pok Phak Rop | Zendy; M. Fornaris | Zendy; Thierry Salmon | Zendy; Joëlle Burle | Zendy; M. Bresson | Zendy

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Concentrations of Heroin, 06-Monoacetylmorphine, and Morphine in a Lethal Case Following an Oral Heroin Overdose

Author(s) -

Pok Phak Rop,

M. Fornaris,

Thierry Salmon,

Joëlle Burle,

M. Bresson

Publication year - 1997

Publication title -

journal of analytical toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.161

H-Index - 76

eISSN - 1945-2403

pISSN - 0146-4760

DOI - 10.1093/jat/21.3.232

Subject(s) - heroin , morphine , urine , ingestion , chemistry , chromatography , gas chromatography–mass spectrometry , codeine , pharmacology , medicine , mass spectrometry , drug , biochemistry

A case of lethal overdose by heroin ingestion is presented. The concentrations of drugs were measured several hours after death. Heroin, 06-monoacetylmorphine, and morphine were identified and quantitated in blood, urine, and gastrointestinal contents by gas chromatography-mass spectrometry and high-performance liquid chromatography. Concentrations of heroin, 06-monoacetylmorphine, and morphine were 109, 168, and 1140 ng/mL, respectively, in blood and 17, 12, and 425 ng/g, respectively, in gastrointestinal content. In urine, however, only morphine was detected at 3650 ng/mL.

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