Comparison of Analytical Methods in the Determination of Two Venlafaxine Fatalities | Zendy

Christopher Long | Zendy; J. A. Crifasi | Zendy; Diane Maginn | Zendy; Michael Graham | Zendy; Shaku Teas | Zendy

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Comparison of Analytical Methods in the Determination of Two Venlafaxine Fatalities

Author(s) -

Christopher Long,

J. A. Crifasi,

Diane Maginn,

Michael Graham,

Shaku Teas

Publication year - 1997

Publication title -

journal of analytical toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.161

H-Index - 76

eISSN - 1945-2403

pISSN - 0146-4760

DOI - 10.1093/jat/21.2.166

Subject(s) - venlafaxine , chromatography , metabolite , high performance liquid chromatography , gas chromatography , chemistry , capillary gas chromatography , medicine , biochemistry , hippocampus , antidepressant

Two venlafaxine (Effexor)-related deaths are reported with comparison of results from the analysis of specimens using capillary gas chromatography with a nitrogen-phosphorous detector (GC-NPD) and high-performance liquid chromatography (HPLC) using a UV-vis detector. Blood concentrations in Case 1 were 7.27 micrograms/mL venlafaxine and 5.03 micrograms/mL O-desmethylvenlafaxine, and Case 2 had 89.67 micrograms/mL venlafaxine with 3.44 micrograms/mL of the desmethyl metabolite. A comparison of analytical methods and specimen concentration is presented.

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