An Overdose of Risperidone | Zendy

Angela C. Springfield | Zendy; Ed Bodiford | Zendy

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An Overdose of Risperidone

Author(s) -

Angela C. Springfield,

Ed Bodiford

Publication year - 1996

Publication title -

journal of analytical toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.161

H-Index - 76

eISSN - 1945-2403

pISSN - 0146-4760

DOI - 10.1093/jat/20.3.202

Subject(s) - risperidone , urine , metabolite , ingestion , gastric fluid , medicine , chromatography , chemistry , pharmacology , schizophrenia (object oriented programming) , psychiatry

A fatality resulting from the suicidal ingestion of risperidone is described. The decedent had a lengthy history of mental illness but was otherwise healthy. Biological fluid samples obtained at autopsy were analyzed for risperidone by high-performance liquid chromatography. The blood concentration of risperidone was 1.8 mg/L, the urine concentration was 14.4 mg/L, and the concentration in the gastric contents was 34.6 mg/L (1.04 mg total). The 9-hydroxy-risperidone metabolite was not detected in the blood or gastric contents; however, the urine contained 17.8 mg/L of this metabolite.

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