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The current experiment was conducted to determine if the dosage or timing of exposure to diets containing high deoxynivalenol (DON), a mycotoxin in a variety of feed ingredients, causes performance loss in nursery pigs. In total, 448 mixed-sex nursery pigs [initial BW = 6.18 ± 0.97 kg] weaned at 21 ± 1 d were allotted to 112 pens, with 4 pigs per pen, in a randomized complete block design. In a 3 x 2 + 1 factorial arrangement of treatments, diets with DON were fed continuously (CONT), at weeks 1 and 3 (WK13), and weeks 2 and 4 (WK24), targeting DON at 1.25 ppm fed (MED), or 2.5 ppm (HIGH), plus the positive control (CONTLOW) for 28 d. All pigs were fed a common, low DON diet from d 28 to 42 to complete the nursery phase. Pen weight and feed intake were measured on d 28 and 42 to calculate ADG and ADFI. Regardless of timing, d 28 BW decreased (P &amp;lt; 0.01) with feeding MED or HIGH diets compared with CONTLOW and markedly decreased (1.57 kg) in the HIGH. This was a response to the decreased ADG (P &amp;lt; 0.01) and ADFI (P &amp;lt; 0.01) from d 0 – 28 in MED or HIGH compared with CONTLOW and with HIGH compared with MED. Similarly, on d 42, performance metrics - BW (P &amp;lt; 0.01), ADG (P &amp;lt; 0.01), and ADFI (P &amp;lt; 0.01) were decreased in MED or HIGH compared with CONTLOW, with a 1.95 kg. decrease in BW in the HIGH compared with CONTLOW. A dose-response to DON was evident whereas, timing of exposure did not affect the performance metrics measured on d 28 or 42. Ultimately, exposure of nursery pigs to levels of DON over 1 ppm results in loss of performance, regardless of exposure timing.

110 Dosage and not Time of Exposure to Deoxynivalenol Affects the Performance of Nursery Pigs Fed High Mycotoxin Diets up to 28 Days Post-Wean