The Common H202D Variant in GDF-15 Does Not Affect Its Bioactivity but Can Significantly Interfere with Measurement of Its Circulating Levels | Zendy

Yanislava Karusheva | Zendy; Matthew Ratcliff | Zendy; Alexander Mörseburg | Zendy; Peter Barker | Zendy; Audrey Melvin | Zendy; Naveed Sattar | Zendy; Keith Burling | Zendy; Anna Backmark | Zendy; Robert Roth | Zendy; Lutz Jermutus | Zendy; Esther GuiuJurado | Zendy; Matthias Blüher | Zendy; Paul Welsh | Zendy; Marko Hyvönen | Zendy; Stephen O’Rahilly | Zendy

Open Access

The Common H202D Variant in GDF-15 Does Not Affect Its Bioactivity but Can Significantly Interfere with Measurement of Its Circulating Levels

Author(s) -

Yanislava Karusheva,

Matthew Ratcliff,

Alexander Mörseburg,

Peter Barker,

Audrey Melvin,

Naveed Sattar,

Keith Burling,

Anna Backmark,

Robert Roth,

Lutz Jermutus,

Esther GuiuJurado,

Matthias Blüher,

Paul Welsh,

Marko Hyvönen,

Stephen O’Rahilly

Publication year - 2022

Publication title -

the journal of applied laboratory medicine

Language(s) - English

Resource type - Journals

eISSN - 2576-9456

pISSN - 2475-7241

DOI - 10.1093/jalm/jfac055

Subject(s) - immunoassay , peptide , gdf15 , chemistry , microbiology and biotechnology , medicine , biology , biochemistry , antibody , immunology

There is growing interest in the measurement of growth differentiation factor 15 (GDF-15) in a range of disorders associated with cachexia. We undertook studies to determine whether a common histidine (H) to aspartate (D) variant at position 202 in the pro-peptide (position 6 in the mature peptide) interfered with its detection by 3 of the most commonly used immunoassays.

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