Multiplex LC-MS/MS Testing for Early Detection of Kidney Injury: A Next-Generation Alternative to Conventional Immunoassays? | Zendy

Tirsa T van Duijl | Zendy; L. Renee Ruhaak | Zendy; Cees van Kooten | Zendy; Johan W. de Fijter | Zendy; Christa M. Cobbaert | Zendy

Open Access

Multiplex LC-MS/MS Testing for Early Detection of Kidney Injury: A Next-Generation Alternative to Conventional Immunoassays?

Author(s) -

Tirsa T van Duijl,

L. Renee Ruhaak,

Cees van Kooten,

Johan W. de Fijter,

Christa M. Cobbaert

Publication year - 2022

Publication title -

the journal of applied laboratory medicine

Language(s) - English

Resource type - Journals

eISSN - 2576-9456

pISSN - 2475-7241

DOI - 10.1093/jalm/jfac024

Subject(s) - immunoassay , chromatography , multiplex , urine , chemistry , mass spectrometry , liquid chromatography–mass spectrometry , medicine , antibody , bioinformatics , biochemistry , immunology , biology

LC-MS/MS has enabled the translation of many novel biomarkers to the clinical laboratory, but its potential for measurement of urinary proteins is still unexplored. In this study we examined the correlation and agreement between immunoassay and LC-MS/MS in the quantitation of kidney injury biomarkers and evaluated the application of technical LC-MS/MS meta-data assessment to ensure test result validity.

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