English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objectives  To analyse the context of genes conferring antibiotic resistance in two carbapenem-resistant  Acinetobacter baumannii  isolates recovered in Tehran, Iran.    Methods  The antibiotic resistance phenotype for 28 antibiotics was determined using disc diffusion. The whole genome sequences of ABH008 and ABS200 were determined using the Illumina HiSeq X Ten platform. Resistance genes were identified using ResFinder and multilocus sequence types were determined using the Oxford and Institut Pasteur schemes.    Results  Isolates ABH008 and ABS200, recovered in 2012 and 2013, respectively, in two different Tehran hospitals, belong to the common global clone 1 lineage, ST1 IP  and ST231 OX . They are resistant to sulfamethoxazole, tetracycline, gentamicin, amikacin, third-generation cephalosporins and carbapenems. Despite being isolated in different hospitals, phylogenetic analysis indicated they are closely related. Consistent with this, both isolates carry  catA1, sul1, aacC1  and  aadA1  in a novel variant of the AbaR3-type resistance island, named AbaR31. Both isolates are resistant to amikacin and carbapenems owing to  aphA6  and  oxa23 , respectively. The  oxa23  gene is located in the AbaR4 resistance island, and  aphA6  in Tn aphA6 , and both mobile elements are in an ∼90 kbp plasmid encoding the putative RepAci6 replication initiation protein. Resistance to third-generation cephalosporins is due to the acquisition by homologous recombination of a 5 kb DNA segment that contains ISAba1- ampC  from a ST623 strain.    Conclusions  The resistance gene complements of ABH008 and ABS200 were found in AbaR31 and a plasmid that encodes RepAci6. The close genetic relationship of ABH008 and ABS200, despite each being recovered from different hospitals, indicates transmission between the two hospitals.

jac-antimicrobial resistance

Two carbapenem-resistant ST1:ST231:KL1:OCL1<i>Acinetobacter baumannii</i>strains recovered in Tehran, Iran, carry AbaR31 in the chromosome and AbaR4 and Tn<i>aphA6</i>in a RepAci6 plasmid

Two carbapenem-resistant ST1:ST231:KL1:OCL1Acinetobacter baumanniistrains recovered in Tehran, Iran, carry AbaR31 in the chromosome and AbaR4 and TnaphA6in a RepAci6 plasmid