Cephalosporin nitric oxide-donor prodrug DEA-C3D disperses biofilms formed by clinical cystic fibrosis isolates of Pseudomonas aeruginosa | Zendy

Odel Soren | Zendy; Ardeshir Rineh | Zendy; Diogo Gonçalves Silva | Zendy; Yu-Ming Cai | Zendy; Robert P. Howlin | Zendy; R N Allan | Zendy; Martin Feelisch | Zendy; Jane C. Davies | Zendy; Gary Connett | Zendy; Saul N. Faust | Zendy; Michael J. Kelso | Zendy; Jeremy S. Webb | Zendy

Open Access

Cephalosporin nitric oxide-donor prodrug DEA-C3D disperses biofilms formed by clinical cystic fibrosis isolates of Pseudomonas aeruginosa

Author(s) -

Odel Soren,

Ardeshir Rineh,

Diogo Gonçalves Silva,

Yu-Ming Cai,

Robert P. Howlin,

R N Allan,

Martin Feelisch,

Jane C. Davies,

Gary Connett,

Saul N. Faust,

Michael J. Kelso,

Jeremy S. Webb

Publication year - 2019

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkz378

Subject(s) - pseudomonas aeruginosa , tobramycin , colistin , biofilm , microbiology and biotechnology , cephalosporin , cystic fibrosis , antibiotics , chemistry , broth microdilution , bacteria , biology , medicine , minimum inhibitory concentration , gentamicin , genetics

The cephalosporin nitric oxide (NO)-donor prodrug DEA-C3D ('DiEthylAmin-Cephalosporin-3'-Diazeniumdiolate') has been shown to initiate the dispersal of biofilms formed by the Pseudomonas aeruginosa laboratory strain PAO1. In this study, we investigated whether DEA-C3D disperses biofilms formed by clinical cystic fibrosis (CF) isolates of P. aeruginosa and its effect in combination with two antipseudomonal antibiotics, tobramycin and colistin, in vitro.

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