An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against MDR Gram-negative bacteria: an in vitro and in vivo study | Zendy

Roger Bayston | Zendy; Waheed Ashraf | Zendy; Iván Pelegrín | Zendy; Katherine Fowkes | Zendy; Alison Bienemann | Zendy; W. Singleton | Zendy; Ian Scott | Zendy

Open Access

An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against MDR Gram-negative bacteria: an in vitro and in vivo study

Author(s) -

Roger Bayston,

Waheed Ashraf,

Iván Pelegrín,

Katherine Fowkes,

Alison Bienemann,

W. Singleton,

Ian Scott

Publication year - 2019

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkz293

Subject(s) - antimicrobial , acinetobacter baumannii , medicine , catheter , antibiotics , acinetobacter , bacteria , microbiology and biotechnology , trimethoprim , rifampicin , surgery , biology , genetics , pseudomonas aeruginosa

External ventricular drainage (EVD) carries a high risk of ventriculitis, increasingly caused by MDR Gram-negative bacteria such as Escherichia coli and Acinetobacter baumannii. Existing antimicrobial EVD catheters are not effective against these, and we have developed a catheter with activity against MDR bacteria and demonstrated the safety of the new formulation for use in the brain.

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