Linezolid resistance in patients with drug-resistant TB and treatment failure in South Africa
Author(s) -
Sean Wasserman,
Gail Louw,
Limpho Ramangoaela,
Garrick Barber,
Cindy Hayes,
Shaheed Vally Omar,
Gary Maartens,
Clifton E. Barry,
Taeksun Song,
Graeme Meintjes
Publication year - 2019
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkz206
Subject(s) - linezolid , drug resistance , genotyping , genotype , medicine , broth microdilution , regimen , rifampicin , antibiotics , minimum inhibitory concentration , tuberculosis , microbiology and biotechnology , biology , vancomycin , genetics , pathology , bacteria , staphylococcus aureus , gene
Limited data exist on clinical associations and genotypic correlates of linezolid resistance in Mycobacterium tuberculosis. We aimed to describe mutations and clinical factors associated with phenotypic linezolid resistance from patients with drug-resistant TB at two public sector facilities in South Africa.
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