Minocycline treatment for pulmonary Mycobacterium avium complex disease based on pharmacokinetics/pharmacodynamics and Bayesian framework mathematical models | Zendy

Mike Marvin Ruth | Zendy; Gesham Magombedze | Zendy; Tawanda Gumbo | Zendy; Paula Bendet | Zendy; Jasper Sangen | Zendy; Sanne M.H. Zweijpfenning | Zendy; Wouter Hoefsloot | Zendy; Lian J. Pennings | Zendy; Valerie A. C. M. Koeken | Zendy; Heiman Wertheim | Zendy; Pooi S Lee | Zendy; Jakko van Ingen | Zendy; Devyani Deshpande | Zendy

Open Access

Minocycline treatment for pulmonary Mycobacterium avium complex disease based on pharmacokinetics/pharmacodynamics and Bayesian framework mathematical models

Author(s) -

Mike Marvin Ruth,

Gesham Magombedze,

Tawanda Gumbo,

Paula Bendet,

Jasper Sangen,

Sanne M.H. Zweijpfenning,

Wouter Hoefsloot,

Lian J. Pennings,

Valerie A. C. M. Koeken,

Heiman Wertheim,

Pooi S Lee,

Jakko van Ingen,

Devyani Deshpande

Publication year - 2019

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkz143

Subject(s) - minocycline , pharmacokinetics , pharmacology , medicine , pharmacodynamics , minimum inhibitory concentration , antibacterial agent , antibiotics , microbiology and biotechnology , biology

Our aim was to identify the pharmacokinetic/pharmacodynamic parameters of minocycline in the hollow-fibre system (HFS) model of pulmonary Mycobacterium avium complex (MAC) and to identify the optimal clinical dose.

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