Pharmacokinetics of ascending doses of ivermectin in Trichuris trichiura-infected children aged 2–12 years | Zendy

Jessica D. Schulz | Zendy; Jean T. Coulibaly | Zendy; Christian Schindler | Zendy; David Wimmersberger | Zendy; Jennifer Keiser | Zendy

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Pharmacokinetics of ascending doses of ivermectin in Trichuris trichiura-infected children aged 2–12 years

Author(s) -

Jessica D. Schulz,

Jean T. Coulibaly,

Christian Schindler,

David Wimmersberger,

Jennifer Keiser

Publication year - 2019

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkz083

Subject(s) - ivermectin , pharmacokinetics , medicine , cmax , trichuris trichiura , gastroenterology , area under the curve , anthelmintic , immunology , veterinary medicine , helminths , ascaris lumbricoides

Yearly, millions of children are treated globally with ivermectin mainly for neglected tropical diseases. Anatomical, physiological and biochemical differences between children and adults may result in changes in pharmacokinetics. However, paediatric pharmacokinetic data of ivermectin are lacking.

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