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The first-line eradication rate of standard triple therapy for Helicobacter pylori infection has declined to &lt;80%, and alternative therapies with &gt;90% success rates are needed. Inconsistent eradication rates were reported for proton pump inhibitor- and amoxicillin-containing high-dose dual therapy.

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

A 14 day esomeprazole- and amoxicillin-containing high-dose dual therapy regimen achieves a high eradication rate as first-line anti-Helicobacter pylori treatment in Taiwan: a prospective randomized trial