Baseline PI susceptibility by HIV-1 Gag-protease phenotyping and subsequent virological suppression with PI-based second-line ART in Nigeria | Zendy

Rawlings Datir | Zendy; Kate El Bouzidi | Zendy; Patrick Dakum | Zendy; Nicaise Ndembi | Zendy; Ravindra K. Gupta | Zendy

Open Access

Baseline PI susceptibility by HIV-1 Gag-protease phenotyping and subsequent virological suppression with PI-based second-line ART in Nigeria

Author(s) -

Rawlings Datir,

Kate El Bouzidi,

Patrick Dakum,

Nicaise Ndembi,

Ravindra K. Gupta

Publication year - 2019

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkz005

Subject(s) - pi , human immunodeficiency virus (hiv) , protease , virology , second line , biology , microbiology and biotechnology , chemistry , medicine , first line , enzyme , biochemistry

Previous work showed that gag-protease-derived phenotypic susceptibility to PIs differed between HIV-1 subtype CRF02_AG/subtype G-infected patients who went on to successfully suppress viral replication versus those who experienced virological failure of lopinavir/ritonavir monotherapy as first-line treatment in a clinical trial. We analysed the relationship between PI susceptibility and outcome of second-line ART in Nigeria, where subtypes CRF02_AG/G dominate the epidemic.

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