Pharmacokinetic-pharmacodynamic modelling to investigate in vitro synergy between colistin and fusidic acid against MDR Acinetobacter baumannii | Zendy

Lynette Phee | Zendy; Frank Kloprogge | Zendy; Rebecca H. Morris | Zendy; John W. Barrett | Zendy; David W. Wareham | Zendy; Joseph F. Standing | Zendy

Open Access

Pharmacokinetic-pharmacodynamic modelling to investigate in vitro synergy between colistin and fusidic acid against MDR Acinetobacter baumannii

Author(s) -

Lynette Phee,

Frank Kloprogge,

Rebecca H. Morris,

John W. Barrett,

David W. Wareham,

Joseph F. Standing

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky524

Subject(s) - colistin , fusidic acid , acinetobacter baumannii , pharmacodynamics , antimicrobial , microbiology and biotechnology , pharmacology , antibiotics , pharmacokinetics , medicine , biology , bacteria , staphylococcus aureus , pseudomonas aeruginosa , genetics

The potential for synergy between colistin and fusidic acid in the treatment of MDR Acinetobacter baumannii has recently been shown. The aim of this study was to perform an extensive in vitro characterization of this effect using pharmacokinetic-pharmacodynamic modelling (PKPD) of time-kill experiments in order to estimate clinical efficacy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research