Surface coatings with covalently attached anidulafungin and micafungin preventCandida albicansbiofilm formation | Zendy

Javad Naderi | Zendy; Carla Giles | Zendy; Solmaz Saboohi | Zendy; Hans J. Griesser | Zendy; Bryan R. Coad | Zendy

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Surface coatings with covalently attached anidulafungin and micafungin preventCandida albicansbiofilm formation

Author(s) -

Javad Naderi,

Carla Giles,

Solmaz Saboohi,

Hans J. Griesser,

Bryan R. Coad

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky437

Subject(s) - anidulafungin , biofilm , echinocandin , echinocandins , micafungin , candida albicans , microbiology and biotechnology , chemistry , biomaterial , corpus albicans , biology , amphotericin b , caspofungin , antifungal , bacteria , organic chemistry , genetics , fluconazole

Fungal biofilms caused by Candida spp. are a major contributor to infections originating from infected biomaterial implants. Since echinocandin-class molecules interfere with the integrity of the fungal cell wall, it was hypothesized that surface-immobilized anidulafungin and micafungin could play a role in preventing fungal adhesion and biofilm formation on surfaces.

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