Importance of routine viral load monitoring: higher levels of resistance at ART failure in Uganda and Lesotho compared with Switzerland
Author(s) -
Nadine Bachmann,
Amrei von Braun,
Niklaus Daniel Labhardt,
Claus Kadelka,
Huldrych F. Günthard,
Christine SekaggyaWiltshire,
Barbara Castelnuovo,
Andrew Kambugu,
Thabo Ishmael Lejone,
Jürg Böni,
Sabine Yerly,
Matthieu Perreau,
Thomas Klimkait,
Roger D. Kouyos,
Jan Fehr,
A Anagnostopoulos,
Manuel Battegay,
Enos Bernasconi,
Dominique L. Braun,
Heiner C. Bucher,
Alexandra Calmy,
Matthias Cavassini,
Angela Ciuffi,
G Dollenmaier,
Matthias Egger,
Luigia Elzi,
Jacques Fellay,
Hansjakob Furrer,
C A Fux,
D Haerry,
Barbara Hasse,
Hans H. Hirsch,
Matthew Hoffmann,
Irène Hösli,
Michael Huber,
Christian R. Kahlert,
Laurent Kaiser,
Olivia Keiser,
Helen Kovari,
B Ledergerber,
G Martinetti,
Begoña Martínez de Tejada,
Catia Marzolini,
Karin J. Metzner,
N Müller,
Dunja Nicca,
P Paioni,
G Pantaleo,
Alan Rauch,
C Rudin,
Alexandra Scherrer,
Patrick Schmid,
R Speck,
Michael Stöckle,
Philip Tarr,
Alexandra Trkola,
Pietro Vernazza,
Gilles Wandeler,
Roger Weber
Publication year - 2018
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dky436
Subject(s) - zidovudine , medicine , viral load , regimen , drug resistance , cohort , population , human immunodeficiency virus (hiv) , antiretroviral therapy , virology , viral disease , biology , environmental health , microbiology and biotechnology
Emerging resistance to antiretroviral drugs may jeopardize the achievements of improved access to ART. We compared the prevalence of different resistance mutations in HIV-infected adults with virological failure in a cohort with regular routine viral load (VL) monitoring (Switzerland) and cohorts with limited access to VL testing (Uganda and Lesotho).
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