Population pharmacokinetics and evaluation of the predictive performance of pharmacokinetic models in critically ill patients receiving continuous infusion meropenem: a comparison of eight pharmacokinetic models | Zendy

Sofie Dhaese | Zendy; Andras Farkas | Zendy; Pieter Colin | Zendy; Jeffrey Lipman | Zendy; Veronique Stove | Zendy; Alain Verstraete | Zendy; Jason A. Roberts | Zendy; Jan J. De Waele | Zendy

Open Access

Population pharmacokinetics and evaluation of the predictive performance of pharmacokinetic models in critically ill patients receiving continuous infusion meropenem: a comparison of eight pharmacokinetic models

Author(s) -

Sofie Dhaese,

Andras Farkas,

Pieter Colin,

Jeffrey Lipman,

Veronique Stove,

Alain Verstraete,

Jason A. Roberts,

Jan J. De Waele

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky434

Subject(s) - meropenem , medicine , dosing , pharmacokinetics , volume of distribution , population , population pharmacokinetics , intensive care unit , therapeutic drug monitoring , intensive care medicine , antibiotics , environmental health , antibiotic resistance , microbiology and biotechnology , biology

Several population pharmacokinetic (PopPK) models for meropenem dosing in ICU patients are available. It is not known to what extent these models can predict meropenem concentrations in an independent validation dataset when meropenem is infused continuously.

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