Novel trimethoprim resistance gene dfrA34 identified in Salmonella Heidelberg in the USA | Zendy

Kaitlin A. Tagg | Zendy; Louise Francois Watkins | Zendy; Matthew D. Moore | Zendy; Christy Bennett | Zendy; Yoo Jin Joung | Zendy; Jessica C. Chen | Zendy; Jason P. Folster | Zendy

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Novel trimethoprim resistance gene dfrA34 identified in Salmonella Heidelberg in the USA

Author(s) -

Kaitlin A. Tagg,

Louise Francois Watkins,

Matthew D. Moore,

Christy Bennett,

Yoo Jin Joung,

Jessica C. Chen,

Jason P. Folster

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky373

Subject(s) - sulfamethoxazole , trimethoprim , salmonella , microbiology and biotechnology , salmonella enterica , serotype , gene , biology , antibiotic resistance , enterobacteriaceae , antibiotics , virology , escherichia coli , bacteria , genetics

Trimethoprim/sulfamethoxazole is a synthetic antibiotic combination recommended for the treatment of complicated non-typhoidal Salmonella infections in humans. Resistance to trimethoprim/sulfamethoxazole is mediated by the acquisition of mobile genes, requiring both a dfr gene (trimethoprim resistance) and a sul gene (sulfamethoxazole resistance) for a clinical resistance phenotype (MIC ≥4/76 mg/L). In 2017, the CDC investigated a multistate outbreak caused by a Salmonella enterica serotype Heidelberg strain with trimethoprim/sulfamethoxazole resistance, in which sul genes but no known dfr genes were detected.

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