Novel synthetic polymyxins kill Gram-positive bacteria | Zendy

Héctor Rudilla | Zendy; Isabel Pérez-Guillén | Zendy; Francesc Rabanal | Zendy; Josep M. Sierra | Zendy; Teresa Vinuesa | Zendy; Miguel Viñas | Zendy

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Novel synthetic polymyxins kill Gram-positive bacteria

Author(s) -

Héctor Rudilla,

Isabel Pérez-Guillén,

Francesc Rabanal,

Josep M. Sierra,

Teresa Vinuesa,

Miguel Viñas

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky366

Subject(s) - staphylococcus aureus , polymyxin , microbiology and biotechnology , colistin , antimicrobial , methicillin resistant staphylococcus aureus , medicine , vancomycin , antibiotics , polymyxin b , tigecycline , biology , bacteria , genetics

Staphylococcus aureus, including 'superbug' MRSA, is a major cause of nosocomial infections. In the European Union, up to 171 200 new nosocomial MRSA infections are acquired annually, and in the USA S. aureus causes more deaths than HIV/AIDS and tuberculosis combined. MRSA is also the first group of pathogens that infect the pulmonary tract in young patients with cystic fibrosis.

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