Open AccessEffect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli
Author(s) -
Linnéa Garoff,
Douglas L. Huseby,
Lisa Praski Alzrigat,
Diarmaid Hughes
Publication year - 2018
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dky356
Subject(s) - biology , genetics , efflux , gene , escherichia coli , mutation , transcriptome , ciprofloxacin , microbiology and biotechnology , antibiotics , gene expression
Chromosomal mutations that reduce ciprofloxacin susceptibility in Escherichia coli characteristically map to drug target genes (gyrAB and parCE), and genes encoding regulators of the AcrAB-TolC efflux pump. Mutations in RNA polymerase can also reduce susceptibility, by up-regulating the MdtK efflux pump.
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