Synergistic activity of an OmpA inhibitor and colistin against colistin-resistant Acinetobacter baumannii: mechanistic analysis and in vivo efficacy | Zendy

Raquel Parra-Millán | Zendy; Xavier VilaFarrés | Zendy; Rafael Ayerbe-Algaba | Zendy; Mónica Varese | Zendy; Viviana Sánchez-Encinales | Zendy; Núria BayóPuxán | Zendy; María Eugenia Pachón-Ibáñez | Zendy; Meritxell Teixidò | Zendy; Jordi Vilà | Zendy; Jerónimo Pachón | Zendy; Ernest Giralt | Zendy; Younes Smani | Zendy

Open Access

Synergistic activity of an OmpA inhibitor and colistin against colistin-resistant Acinetobacter baumannii: mechanistic analysis and in vivo efficacy

Author(s) -

Raquel Parra-Millán,

Xavier VilaFarrés,

Rafael Ayerbe-Algaba,

Mónica Varese,

Viviana Sánchez-Encinales,

Núria BayóPuxán,

María Eugenia Pachón-Ibáñez,

Meritxell Teixidò,

Jordi Vilà,

Jerónimo Pachón,

Ernest Giralt,

Younes Smani

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky343

Subject(s) - acinetobacter baumannii , colistin , microbiology and biotechnology , in vivo , biology , acinetobacter , antibiotics , bacteria , pseudomonas aeruginosa , genetics

Preventing bacterial contact with host cells can provide an additional approach to tackling MDR Acinetobacter baumannii. Recently, we identified AOA-2 as a potential blocker of A. baumannii outer membrane protein A without presenting bactericidal activity. Here, we aimed to study whether AOA-2 can increase the activity of colistin against colistin-resistant A. baumannii in vitro and in vivo.

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