Colistin susceptibility test evaluation of multiple-resistance-level Pseudomonas aeruginosa isolates generated in a morbidostat device | Zendy

Mumina Javed | Zendy; Viola Ueltzhoeffer | Zendy; Maximilian Heinrich | Zendy; Hans Justus Siegrist | Zendy; Ronja Wildermuth | Zendy; Freia-Raphaella Lorenz | Zendy; Richard A. Neher | Zendy; Matthias Willmann | Zendy

Open Access

Colistin susceptibility test evaluation of multiple-resistance-level Pseudomonas aeruginosa isolates generated in a morbidostat device

Author(s) -

Mumina Javed,

Viola Ueltzhoeffer,

Maximilian Heinrich,

Hans Justus Siegrist,

Ronja Wildermuth,

Freia-Raphaella Lorenz,

Richard A. Neher,

Matthias Willmann

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky337

Subject(s) - colistin , pseudomonas aeruginosa , microbiology and biotechnology , polymyxin , medicine , biology , antibiotics , bacteria , genetics

Colistin is a last-resort antibiotic against the critical-status pathogen Pseudomonas aeruginosa. There is still uncertainty regarding how to accurately measure colistin susceptibility in P. aeruginosa. Evaluation of antimicrobial susceptibility testing (AST) methods is largely hampered by the lack of resistant isolates and those around the susceptibility breakpoint. The aim of this study was to generate such strains in a morbidostat device for use in AST method evaluation.

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