Rapid detection and discrimination of chromosome- and MCR-plasmid-mediated resistance to polymyxins by MALDI-TOF MS in Escherichia coli: the MALDIxin test | Zendy

Laurent Dortet | Zendy; Rémy A. Bonnin | Zendy; Ivana Pennisi | Zendy; Lauraine Gauthier | Zendy; Agnès B. Jousset | Zendy; Laura Dabos | Zendy; R. Christopher D. Furniss | Zendy; Despoina A.I. Mavridou | Zendy; Pierre Bogaerts | Zendy; Y. Glupczynski | Zendy; Anaïs Potron | Zendy; Patrick Plésiat | Zendy; Racha Beyrouthy | Zendy; Frédéric Robin | Zendy; Richard Bonnet | Zendy; Thierry Naas | Zendy; Alain Filloux | Zendy; Gérald Larrouy-Maumus | Zendy

Open Access

Rapid detection and discrimination of chromosome- and MCR-plasmid-mediated resistance to polymyxins by MALDI-TOF MS in Escherichia coli: the MALDIxin test

Author(s) -

Laurent Dortet,

Rémy A. Bonnin,

Ivana Pennisi,

Lauraine Gauthier,

Agnès B. Jousset,

Laura Dabos,

R. Christopher D. Furniss,

Despoina A.I. Mavridou,

Pierre Bogaerts,

Y. Glupczynski,

Anaïs Potron,

Patrick Plésiat,

Racha Beyrouthy,

Frédéric Robin,

Richard Bonnet,

Thierry Naas,

Alain Filloux,

Gérald Larrouy-Maumus

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky330

Subject(s) - polymyxin , plasmid , escherichia coli , microbiology and biotechnology , enterobacteriaceae , biology , bacteria , polymyxin b , lipid a , chromosome , genetics , gene

Polymyxins are currently considered a last-resort treatment for infections caused by MDR Gram-negative bacteria. Recently, the emergence of carbapenemase-producing Enterobacteriaceae has accelerated the use of polymyxins in the clinic, resulting in an increase in polymyxin-resistant bacteria. Polymyxin resistance arises through modification of lipid A, such as the addition of phosphoethanolamine (pETN). The underlying mechanisms involve numerous chromosome-encoded genes or, more worryingly, a plasmid-encoded pETN transferase named MCR. Currently, detection of polymyxin resistance is difficult and time consuming.

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