Ultra-deep sequencing improves the detection of drug resistance in cellular DNA from HIV-infected patients on ART with suppressed viraemia | Zendy

Christophe Rodriguez | Zendy; Marie Laure Néré | Zendy; Vanessa Démontant | Zendy; Isabelle Charreau | Zendy; Mélanie Mercier-Darty | Zendy; Héloïse Delagrèverie | Zendy; Maud Salmona | Zendy; Nathalie De Castro | Zendy; MarieLaure Chaix | Zendy; JeanMichel Molina | Zendy; Constance Delaugerre | Zendy

Open Access

Ultra-deep sequencing improves the detection of drug resistance in cellular DNA from HIV-infected patients on ART with suppressed viraemia

Author(s) -

Christophe Rodriguez,

Marie Laure Néré,

Vanessa Démontant,

Isabelle Charreau,

Mélanie Mercier-Darty,

Héloïse Delagrèverie,

Maud Salmona,

Nathalie De Castro,

MarieLaure Chaix,

JeanMichel Molina,

Constance Delaugerre

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky315

Subject(s) - genotype , biology , dna sequencing , reverse transcriptase , virology , drug resistance , dna , hiv drug resistance , resistance mutation , deep sequencing , gene , polymerase chain reaction , microbiology and biotechnology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , genetics , genome

Standard genotypic tests performed on HIV DNA from patients on suppressive ART, with previous resistance-associated mutations (RAMs) detected in their plasma, underestimate resistance. We thus compared ultra-deep sequencing (UDS) with bulk sequencing of DNA to detect RAMs previously identified in plasma.

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