High prevalence and long duration of nervous system and psychiatric adverse drug reactions in Ugandan patients taking efavirenz 600 mg daily | Zendy

Kay Seden | Zendy; Daniel Kiiza | Zendy; Eva Laker | Zendy; Walter Joseph Arinaitwe | Zendy; Catriona Waitt | Zendy; Mohammed Lamorde | Zendy; Saye Khoo | Zendy

Open Access

High prevalence and long duration of nervous system and psychiatric adverse drug reactions in Ugandan patients taking efavirenz 600 mg daily

Author(s) -

Kay Seden,

Daniel Kiiza,

Eva Laker,

Walter Joseph Arinaitwe,

Catriona Waitt,

Mohammed Lamorde,

Saye Khoo

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky298

Subject(s) - efavirenz , medicine , adverse effect , drug , drug reaction , psychiatry , duration (music) , pediatrics , human immunodeficiency virus (hiv) , virology , antiretroviral therapy , viral load , art , literature

Efavirenz-related nervous system or psychiatric adverse drug reactions (ADRs) are conventionally reported to resolve soon after initiation, with incidence of dizziness at 8.5% in large clinical trials. Patients of black ethnicity are genetically at greater risk of elevated efavirenz exposure, which has been linked to nervous system toxicity.

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