Lack of dermal penetration of topically applied gentamicin as pharmacokinetic evidence indicating insufficient efficacy | Zendy

Zoe Oesterreicher | Zendy; Edith Lackner | Zendy; Walter Jäger | Zendy; Martina Höferl | Zendy; Markus Zeitlinger | Zendy

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Lack of dermal penetration of topically applied gentamicin as pharmacokinetic evidence indicating insufficient efficacy

Author(s) -

Zoe Oesterreicher,

Edith Lackner,

Walter Jäger,

Martina Höferl,

Markus Zeitlinger

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky274

Subject(s) - cmax , gentamicin , pharmacokinetics , staphylococcus aureus , medicine , antibiotics , pharmacology , penetration (warfare) , pseudomonas aeruginosa , microbiology and biotechnology , biology , bacteria , genetics , operations research , engineering

Treatment of skin and superficial soft tissue infections with topically applied antibiotics is a controversial topic, because only few clinical studies exist and target site concentrations after topical treatment are widely unknown.

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