Impact of natural polymorphisms of HIV-1 non-group M on genotypic susceptibility to the attachment inhibitor fostemsavir | Zendy

Élodie Alessandri-Gradt | Zendy; Charlotte Charpentier | Zendy; Marie Leoz | Zendy; Thomas Mourez | Zendy; Diane Descamps | Zendy; JeanChristophe Plantier | Zendy

Open Access

Impact of natural polymorphisms of HIV-1 non-group M on genotypic susceptibility to the attachment inhibitor fostemsavir

Author(s) -

Élodie Alessandri-Gradt,

Charlotte Charpentier,

Marie Leoz,

Thomas Mourez,

Diane Descamps,

JeanChristophe Plantier

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky271

Subject(s) - genotype , biology , genetics , human immunodeficiency virus (hiv) , group a , genetic diversity , virology , gene , population , medicine , environmental health

Fostemsavir belongs to the new class of attachment inhibitors (AIs); it inhibits the entry of HIV into CD4+ T-lymphocytes by blocking conformational changes in gp120. This is a promising AI, but previous phenotypic data showed that genetically divergent HIV-1 group O could present natural resistance to this drug. These data were obtained from only two strains, which are not representative of the high intra-group genetic diversity. Moreover, no data are available concerning the other divergent HIV-1 groups (N and P).

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