Antibacterial activity and mechanism of action of analogues derived from the antimicrobial peptide mBjAMP1 isolated from Branchiostoma japonicum | Zendy

Jonggwan Park | Zendy; Hee Kyoung Kang | Zendy; MoonChang Choi | Zendy; Jeong Don Chae | Zendy; Byoung Kwan Son | Zendy; Yong Pil Chong | Zendy; Chang Ho Seo | Zendy; Yoonkyung Park | Zendy

Open Access

Antibacterial activity and mechanism of action of analogues derived from the antimicrobial peptide mBjAMP1 isolated from Branchiostoma japonicum

Author(s) -

Jonggwan Park,

Hee Kyoung Kang,

MoonChang Choi,

Jeong Don Chae,

Byoung Kwan Son,

Yong Pil Chong,

Chang Ho Seo,

Yoonkyung Park

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky144

Subject(s) - antimicrobial , mechanism of action , peptide , antimicrobial peptides , microbiology and biotechnology , antibacterial agent , mechanism (biology) , chemistry , action (physics) , antibacterial activity , biology , pharmacology , bacteria , antibiotics , biochemistry , in vitro , genetics , philosophy , physics , epistemology , quantum mechanics

The worldwide increase in antibiotic-resistant bacteria is a growing threat to public health. Antimicrobial peptides (AMPs) are potentially effective alternatives to conventional antibiotics. We therefore tested analogues of the AMP mBjAMP1 from Branchiostoma japonicum, which we produced by adding and/or replacing amino acids to increase antimicrobial activity against Gram-negative bacteria.

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