In vitro activity of ceftaroline against clinical Staphylococcus aureus isolates collected during a national survey conducted in Belgian hospitals | Zendy

M. Ángeles Argudín | Zendy; M Dodémont | Zendy; M. Taguemount | Zendy; S Roisin | Zendy; R de Mendonça | Zendy; A Deplano | Zendy; C hoff | Zendy; O Denis | Zendy

Open Access

In vitro activity of ceftaroline against clinical Staphylococcus aureus isolates collected during a national survey conducted in Belgian hospitals

Author(s) -

M. Ángeles Argudín,

M Dodémont,

M. Taguemount,

S Roisin,

R de Mendonça,

A Deplano,

C hoff,

O Denis

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky140

Subject(s) - staphylococcus aureus , microbiology and biotechnology , cephalosporin , in vitro , medicine , methicillin resistant staphylococcus aureus , antibiotics , biology , bacteria , biochemistry , genetics

Methods: From October 2013 to March 2014, 155 laboratories of Belgian acute-care hospitals were invited to send to the National Reference Centre—Staphylococcus aureus (Belgium) up to five non-duplicate S. aureus including three MRSA and two MSSA from hospitalized patients. Isolates were analysed by spa typing, SCCmec typing (for MRSA) and PCR for detection of 16S-mecA-nuc and 16S-mecC. MICs of oxacillin, cefoxitin and ceftaroline were determined by the broth microdilution method. The nucleotide sequences of mecA, native pbp and gdpP genes of isolates with reduced susceptibility to ceftaroline were analysed for the presence of mutations responsible for amino acid substitutions.

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