Efflux pump inhibitor CCCP to rescue colistin susceptibility in mcr-1 plasmid-mediated colistin-resistant strains and Gram-negative bacteria | Zendy

Sophie Alexandra Baron | Zendy; JeanMarc Rolain | Zendy

Open Access

Efflux pump inhibitor CCCP to rescue colistin susceptibility in mcr-1 plasmid-mediated colistin-resistant strains and Gram-negative bacteria

Author(s) -

Sophie Alexandra Baron,

JeanMarc Rolain

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky134

Subject(s) - colistin , efflux , microbiology and biotechnology , bacteria , biology , enterobacter , serratia marcescens , gram negative bacteria , mcr 1 , morganella morganii , enterobacteriaceae , antibiotics , escherichia coli , biochemistry , genetics , gene

Efflux in bacteria is a ubiquitous mechanism associated with resistance to antimicrobials agents. Efflux pump inhibitors (EPIs) have been developed to inhibit efflux mechanisms and could be a good alternative to reverse colistin resistance, but only CCCP has shown good activity. The aim of our study was to identify CCCP activity in a collection of 93 Gram-negative bacteria with known and unknown colistin resistance mechanisms including isolates with mcr-1 plasmid-mediated colistin resistance.

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