Antibiotic pressure on the acquisition and loss of antibiotic resistance genes in Klebsiella pneumoniae | Zendy

Patricia J. Simner | Zendy; Annukka A.R. Antar | Zendy; Stephanie Hao | Zendy; James Gurtowski | Zendy; Pranita D. Tamma | Zendy; Clare Rock | Zendy; Belita N. A. Opene | Zendy; Tsigereda Tekle | Zendy; Karen C. Carroll | Zendy; Michael C. Schatz | Zendy; Winston Timp | Zendy

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Antibiotic pressure on the acquisition and loss of antibiotic resistance genes in Klebsiella pneumoniae

Author(s) -

Patricia J. Simner,

Annukka A.R. Antar,

Stephanie Hao,

James Gurtowski,

Pranita D. Tamma,

Clare Rock,

Belita N. A. Opene,

Tsigereda Tekle,

Karen C. Carroll,

Michael C. Schatz,

Winston Timp

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky121

Subject(s) - klebsiella pneumoniae , plasmid , resistome , microbiology and biotechnology , meropenem , virulence , biology , carbapenem , antibiotic resistance , multilocus sequence typing , drug resistance , antibiotics , gene , virology , genetics , genotype , escherichia coli , integron

In this study, we characterize a concurrent disseminated infection with a virulent hypermucoviscous (HMV) Klebsiella pneumoniae and an OXA-181-producing XDR K. pneumoniae from a patient with recent hospitalization in India. During exposure to meropenem therapy, the highly susceptible HMV K. pneumoniae became resistant to carbapenems, consistent with the acquisition of blaOXA-181.

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