Plasma cystatin C as a marker for estimated glomerular filtration rate assessment in HIV-1-infected patients treated with dolutegravir-based ART | Zendy

Romain Palich | Zendy; Roland Tubiana | Zendy; Besma Abdi | Zendy; Fouzi Mestari | Zendy; Marguerite Guiguet | Zendy; Françoise ImbertBismut | Zendy; Christine Katlama | Zendy; Dominique Bonnefont–Rousselot | Zendy; Corinne Isnard Bagnis | Zendy

Open Access

Plasma cystatin C as a marker for estimated glomerular filtration rate assessment in HIV-1-infected patients treated with dolutegravir-based ART

Author(s) -

Romain Palich,

Roland Tubiana,

Besma Abdi,

Fouzi Mestari,

Marguerite Guiguet,

Françoise ImbertBismut,

Christine Katlama,

Dominique Bonnefont–Rousselot,

Corinne Isnard Bagnis

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky112

Subject(s) - dolutegravir , cystatin c , renal function , creatinine , urology , medicine , cystatin , endocrinology , viral load , gastroenterology , human immunodeficiency virus (hiv) , antiretroviral therapy , immunology

Inhibition of the organic cation transporter-2 renal tubule transporter by dolutegravir leads to serum creatinine increase. Serum cystatin C is a non-organic cation transporter-2-dependent marker, possibly enabling glomerular filtration rate (GFR) estimation under dolutegravir. Our goal was to evaluate the changes in creatinine- and cystatin C-based estimated GFR values before and after dolutegravir initiation.

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