Evaluation of voriconazole anti-Acanthamoeba polyphaga in vitro activity, rat cornea penetration and efficacy against experimental rat Acanthamoeba keratitis | Zendy

J. Gueudry | Zendy; Laëtitia Le Goff | Zendy; Patricia Compag | Zendy; Sabine Lefèvre | Zendy; Élodie Colasse | Zendy; Camille Aknine | Zendy; François Duval | Zendy; Arnaud François | Zendy; Romy Razakandrainibe | Zendy; J. Ballet | Zendy; M. Muraine | Zendy; Loïc Favennec | Zendy

Open Access

Evaluation of voriconazole anti-Acanthamoeba polyphaga in vitro activity, rat cornea penetration and efficacy against experimental rat Acanthamoeba keratitis

Author(s) -

J. Gueudry,

Laëtitia Le Goff,

Patricia Compag,

Sabine Lefèvre,

Élodie Colasse,

Camille Aknine,

François Duval,

Arnaud François,

Romy Razakandrainibe,

J. Ballet,

M. Muraine,

Loïc Favennec

Publication year - 2018

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dky094

Subject(s) - voriconazole , acanthamoeba , acanthamoeba keratitis , cornea , keratitis , pharmacology , fungal keratitis , microbiology and biotechnology , eye drop , medicine , biology , ophthalmology , antifungal

Acanthamoeba keratitis (AK) is a sight-threatening infectious disease. Its effective and safe medical therapy remains highly debated. Recently, voriconazole, a monotriazole with noted in vitro activity against a large variety of fungi, has been successfully used both topically and systemically to treat human AK cases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research